This document is a Guide to Action for mainstreaming lifelong learning as a key driver to achieve the 17 Sustainable Development Goals (SDGs). The document seeks to facilitate the process of transforming global goals into local actions by showing concrete steps, which members of the UNESCO Global Network of Learning Cities (GNLC) have taken to promote green and healthy environments, equity and inclusion as well as decent work and entrepreneurship. This Guide to Action is closely linked to the Cork Call to Action for Learning Cities, adopted by the participants of the third International Conference on Learning Cities, which took place from 18–20 September 2017 in Cork, Ireland.