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The research object of this article is to identify the different epistemological and methodological perspectives that have emerged from the global South. It also addresses the irruption of globalization and cross-border processes of climate change from the called “epistemology of the South” perspective. As a result, it claims the need for cross-cultural bridges between people from all over the world to overcome the paradigmatic crossroads at which we find ourselves as a world-system, with the aim to achieve the Sustainable Development Goals set by the United Nations for the year 2030.