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There are several efforts to promote multiculturalism and decolonization in higher education, but their application has limitations. This article notes that often these issues are discussed under the influences of history in primary and secondary education that not correspond to higher education and universities reality. In other cases they are addressed as primarily cultural and folclorized problems. To attend this issue, this chapter suggest a reconceptualization of culture and a more integral, materialist and political historical and institutional analysis of interculturality and decolonization in universities. In these way, tried to explain the difficulties in applying the current educational reform at the higher education.