Alterstice has been offering, for ten years, a unique space for scientific production responding to socially acute questions related to the consideration of inter-individual, social, and societal diversity. This thematic issue is linked to the creation in 2017 of a thematic axis within the International Association for Intercultural Research (ARIC). This network has enabled researchers to organize symposia questioning disability, intersectionality, and how the work carried out in more mainstream currents take into account or not the intercultural dimension to study the paradigm shift of disability. Fifteen years after the launch of the International Convention on the Rights of Persons with Disabilities (CRPD) marks a societal desire to renew living together at the international level as well as at the national level for the countries that have ratified it, as revealed by the work scientific studies carried out from an intercultural perspective. After an introduction to the notions of disability and interculturality, which also refer to designation processes, which may or may not be crossed and compared in scientific analysis. From a multidisciplinary perspective, different angles relating to the diversity of representations of disability and the issues it raises in situations of contact between cultures are discussed.